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Results Treatment with a single dose of MTX significantly boosted serum nephrotoxicity as well as hepatotoxicity indices

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In turn, nicotinamide is produced by various NAD + -consuming enzymes, such as poly-adenosine diphosphate-ribose polymerase (PARPs) isoforms, which are involved in DNA repair [72], and sirtuins (SIRTs), also known as NAD + -dependent protein deacetylases, that are involved in numerous cellular processes, including inflammation and energy metabolism [73, 74]

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